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Mutagenesis Pregabalin was not mutagenic in germs or in mammalian cells in vitro, wasn't clastogenic in mammalian systems in vitro and in vivo, and did not induce unscheduled DNA synthesis in mouse or rat hepatocytes.In the 3rd review (E3), a similar overall every day dose was divided into two equal doses for a single team (twice daily dosing) and